Phosphorylation of membrane components of adrenal chromaffin granules by adenosine triphosphate.
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چکیده
HERBERT SHEPPARD AND CHARLES II. BURGHARDT. The Effect of Alpha, Bela, and Dopamine Receptor-Blocking Agents oii the Stimulation of Rat Eryt hrocyte Adenyl Cyclase by Dihydroxyphenethylamines and Their -Hydroxylated Derivatives 1 0. A. SHE IIsA AND L. A. FAHIEN. Modifications of Glutamate Dehydrogenase by Various Drugs Which Affect Behavior S 1 ENNETH C. LEIBMAN AND RONALD W. ESTABROOK. Effects of Extraction with Isooctane upon the Properties of Liver Microsomes 26 G. 1 ATO AND J. YUNG. The Use of Nuclear Magnetic Resonance to Describe the
منابع مشابه
Phosphatidylinositol kinase. A component of the chromaffin-granule membrane.
Phosphorylation of bovine chromaffin granules by ATP leads to the formation of diphosphoinositide in the granule membrane. Both phosphatidylinositol kinase and its substrate are components of this membrane, and triphosphoinositide is not formed under the conditions of the assay. The reaction is Mg(2+)-dependent and is stimulated by Mn(2+) and F(-) ions. The initial reaction is rapid, with a bro...
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The chromaffin granules (vesicles storing catecholamines, nucleotides and other components of adrenal medullary cells [I] represent a classic model system for exocytotic hormone release from secretory cells [2]. Exocytosis is assumed to involve binding of the storage vesicles to and fusion with, the plasma membrane, and possibly dissociation of (empty) vesicles from exocytotic sites. Recent evi...
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Chromaffin granules suspended in C1-containing media release catecholamine and protein when ATP is added. This phenomenon is inhibited in hyperosmotic media and in the presence of uncouplers of oxidative phosphorylation. Release requires a permeant anion in the medium, but is independent of the cation. The release process appears to be driven by an inwardly directed proton-translocating adenosi...
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In the presence of high concentrations of free Ca2+ (10(-5) - 10(-4) M) chromaffin granules and adrenal medullary mitochondria take up large amounts of Ca2+. At low levels of buffered free Ca2+ (less than 10(-8) M), these mitochondria release almost all of their stored calcium, whereas chromaffin granules retain the major part of their calcium pool. In the presence of MgATP and at less than 10(...
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عنوان ژورنال:
- Molecular pharmacology
دوره 7 1 شماره
صفحات -
تاریخ انتشار 1971